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Differential Requirement for CD70 and CD80/CD86 in Dendritic Cell-mediated Activation of Tumor Tolerized CD8 T Cells

A major obstacle to efficacious T cell-based cancer immunotherapy is the tolerizing tumor microenvironment that rapidly inactivates tumor-infiltrating lymphocytes. In an autochthonous model of prostate cancer, we have previously shown that intratumoral injection of antigen loaded dendritic cells (DC...

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Main Authors: Bak, S. Peter, Barnkob, Mike Stein, Bai, Ailin, Higham, Eileen M., Wittrup, K. Dane, Chen, Jianzhu
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060810/
https://ncbi.nlm.nih.gov/pubmed/22798683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201271
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