Rapid tolerization of virus-activated tumor-specific CD8(+) T cells in prostate tumors of TRAMP mice

To study T cell responses to tumors in an autochthonous model, we expressed a CD8 T cell epitope SIYRYYGL (SIY) in the prostate of transgenic adenocarcinoma (TRAMP) mice (referred to as TRP-SIY), which spontaneously develop prostate cancer. Naïve SIY-specific CD8 T cells adoptively transferred into...

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Bibliographic Details
Main Authors: Bai, Ailin, Higham, Eileen, Eisen, Herman N., Wittrup, K. Dane, Chen, Jianzhu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519043/
https://ncbi.nlm.nih.gov/pubmed/18723683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805599105
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