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The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment
Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here we report...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060806/ https://ncbi.nlm.nih.gov/pubmed/24784029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4818 |
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