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Removing T-cell epitopes with computational protein design
Immune responses can make protein therapeutics ineffective or even dangerous. We describe a general computational protein design method for reducing immunogenicity by eliminating known and predicted T-cell epitopes and maximizing the content of human peptide sequences without disrupting protein stru...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060723/ https://ncbi.nlm.nih.gov/pubmed/24843166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321126111 |
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