Use of transmission electron microscopy to identify nanocrystals of challenging protein targets

The current practice for identifying crystal hits for X-ray crystallography relies on optical microscopy techniques that are limited to detecting crystals no smaller than 5 μm. Because of these limitations, nanometer-sized protein crystals cannot be distinguished from common amorphous precipitates,...

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Detalhes bibliográficos
Main Authors: Stevenson, Hilary P., Makhov, Alexander M., Calero, Monica, Edwards, Andrea L., Zeldin, Oliver B., Mathews, Irimpan I., Lin, Guowu, Barnes, Christopher O., Santamaria, Hugo, Ross, Ted M., Soltis, S. Michael, Khosla, Chaitan, Nagarajan, V., Conway, James F., Cohen, Aina E., Calero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060711/
https://ncbi.nlm.nih.gov/pubmed/24872454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400240111
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