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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak
Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members such as Bcl-2, myeloid cell leukemia 1 (Mcl-1), and B-cell lymphoma-X large (Bcl-xL) are proposed to inhibit autophagy by directly binding to the BH3 domain of Beclin 1/Atg6. However, these Bcl-2 family proteins also block the proapoptotic activ...
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| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060681/ https://ncbi.nlm.nih.gov/pubmed/24912196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406425111 |
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