Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present biochemical, structural, and cell-based evidence demo...

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Detaylı Bibliyografya
Asıl Yazarlar: Chong, Robert A., Wu, Kenneth, Spratt, Donald E., Yang, Yingying, Lee, Chan, Nayak, Jaladhi, Xu, Ming, Elkholi, Rana, Tappin, Inger, Li, Jessica, Hurwitz, Jerard, Brown, Brian D., Chipuk, Jerry Edward, Chen, Zhijian J., Sanchez, Roberto, Shaw, Gary S., Huang, Lan, Pan, Zhen-Qiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060658/
https://ncbi.nlm.nih.gov/pubmed/24912152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407849111
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