Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present biochemical, structural, and cell-based evidence demo...

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Detalhes bibliográficos
Main Authors: Chong, Robert A., Wu, Kenneth, Spratt, Donald E., Yang, Yingying, Lee, Chan, Nayak, Jaladhi, Xu, Ming, Elkholi, Rana, Tappin, Inger, Li, Jessica, Hurwitz, Jerard, Brown, Brian D., Chipuk, Jerry Edward, Chen, Zhijian J., Sanchez, Roberto, Shaw, Gary S., Huang, Lan, Pan, Zhen-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060658/
https://ncbi.nlm.nih.gov/pubmed/24912152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407849111
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