Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present biochemical, structural, and cell-based evidence demo...

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Détails bibliographiques
Auteurs principaux: Chong, Robert A., Wu, Kenneth, Spratt, Donald E., Yang, Yingying, Lee, Chan, Nayak, Jaladhi, Xu, Ming, Elkholi, Rana, Tappin, Inger, Li, Jessica, Hurwitz, Jerard, Brown, Brian D., Chipuk, Jerry Edward, Chen, Zhijian J., Sanchez, Roberto, Shaw, Gary S., Huang, Lan, Pan, Zhen-Qiang
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060658/
https://ncbi.nlm.nih.gov/pubmed/24912152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407849111
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