Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor γt production in macrophages and repression of classically activated macrophages

INTRODUCTION: Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA). METHODS: IL-10-knockout (IL-10(−/−)) mice and wild-type (WT) mice...

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Detalhes bibliográficos
Main Authors: Ye, Liang, Wen, Zhongyang, Li, Yanqun, Chen, Bingni, Yu, Ting, Liu, Lanying, Zhang, Jinshun, Ma, Yanmei, Xiao, Shuying, Ding, Liping, Li, Li, Huang, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060547/
https://ncbi.nlm.nih.gov/pubmed/24742125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4544
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