Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1

INTRODUCTION: Although the pathogenesis of systemic sclerosis (SSc) still remains unknown, recent studies have demonstrated that endothelins are deeply involved in the developmental process of fibrosis and vasculopathy associated with SSc, and a dual endothelin receptor antagonist, bosentan, has a p...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Akamata, Kaname, Asano, Yoshihide, Aozasa, Naohiko, Noda, Shinji, Taniguchi, Takashi, Takahashi, Takehiro, Ichimura, Yohei, Toyama, Tetsuo, Sato, Shinichi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060196/
https://ncbi.nlm.nih.gov/pubmed/24708674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4529
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