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Defective Transport of the Obesity Mutant PC1/3 N222D Contributes to Loss of Function
Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Endocrine Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060179/ https://ncbi.nlm.nih.gov/pubmed/24828610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1985 |
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