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Defective Transport of the Obesity Mutant PC1/3 N222D Contributes to Loss of Function

Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the...

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Detalhes bibliográficos
Main Authors: Prabhu, Yogikala, Blanco, Elias H., Liu, Ming, Peinado, Juan R., Wheeler, Matthew C., Gekakis, Nicholas, Arvan, Peter, Lindberg, Iris
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060179/
https://ncbi.nlm.nih.gov/pubmed/24828610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1985
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