SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related damage to mitochondria may be a critical feature, which manifests in an exacerbation of IR injury. Silent information regulator of transcription 3 (SIRT3), the maj...

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Bibliografiske detaljer
Main Authors: Porter, George A., Urciuoli, William R., Brookes, Paul S., Nadtochiy, Sergiy M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
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Call for Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059981/
https://ncbi.nlm.nih.gov/pubmed/24748594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00027.2014
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