Ethanol Alters Local Cellular Levels of (3α,5α)-3-Hydroxypregnan-20-one (3α,5α-THP) Independent of the Adrenals in Subcortical Brain Regions

The neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP or allopregnanolone) is a positive modulator of GABA(A) receptors synthesized in the brain, adrenal glands, and gonads. In rats, ethanol activates the hypothalamic–pituitary–adrenal axis and elevates 3α,5α-THP in plasma, cerebral cor...

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Détails bibliographiques
Auteurs principaux: Cook, Jason B, Nelli, Stephanie M, Neighbors, Mackenzie R, Morrow, Danielle H, O'Buckley, Todd K, Maldonado-Devincci, Antoniette M, Morrow, A Leslie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059907/
https://ncbi.nlm.nih.gov/pubmed/24566803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.46
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