Identification of residues linked to the slow-->fast transition of thrombin.
Residues energetically linked to the allosteric transition of thrombin from its anticoagulant slow form to the procoagulant fast form have been identified by site-directed mutagenesis. The energetics of recognition by the two forms of the enzyme were probed by using a synthetic chromogenic substrate...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1995
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479962/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11185 |
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