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Identification of residues linked to the slow-->fast transition of thrombin.

Residues energetically linked to the allosteric transition of thrombin from its anticoagulant slow form to the procoagulant fast form have been identified by site-directed mutagenesis. The energetics of recognition by the two forms of the enzyme were probed by using a synthetic chromogenic substrate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Guinto, E R, Vindigni, A, Ayala, Y M, Dang, Q D, Di Cera, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40596/
https://ncbi.nlm.nih.gov/pubmed/7479962
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