Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases.
Residue 225 in serine proteases is typically Pro or Tyr and specifies an important and unanticipated functional aspect of this class of enzymes. Proteases with Y225, like thrombin, are involved in highly specialized functions like blood coagulation and complement that are exclusively found in verteb...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855234/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.10653 |
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