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Identification of residues linked to the slow-->fast transition of thrombin.

Residues energetically linked to the allosteric transition of thrombin from its anticoagulant slow form to the procoagulant fast form have been identified by site-directed mutagenesis. The energetics of recognition by the two forms of the enzyme were probed by using a synthetic chromogenic substrate...

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Hlavní autoři: Guinto, E R, Vindigni, A, Ayala, Y M, Dang, Q D, Di Cera, E
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC40596/
https://ncbi.nlm.nih.gov/pubmed/7479962
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