Identification of residues linked to the slow-->fast transition of thrombin.

Residues energetically linked to the allosteric transition of thrombin from its anticoagulant slow form to the procoagulant fast form have been identified by site-directed mutagenesis. The energetics of recognition by the two forms of the enzyme were probed by using a synthetic chromogenic substrate...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Guinto, E R, Vindigni, A, Ayala, Y M, Dang, Q D, Di Cera, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479962/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11185
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