Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion

Early in the pathogenesis of Type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic α-cells occurs prior to impaired glucose stimulated insulin secretion (GSIS) from β-cells. However, whether hyperglucagonemia is causally linked to β-cell dysfunction remains unclear. Here w...

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Bibliographic Details
Main Authors: Song, Woo-Jin, Mondal, Prosenjit, Wolfe, Andrew, Alonso, Laura C., Stamateris, Rachel, Ong, Benny W. T., Lim, Owen C., Yang, Kil S., Radovick, Sally, Novaira, Horacio F., Farber, Emily A., Farber, Charles R., Turner, Stephen D., Hussain, Mehboob A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058888/
https://ncbi.nlm.nih.gov/pubmed/24703698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.005
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