Glucagon Regulates Hepatic Kisspeptin1 to Impair Insulin Secretion

Early in the pathogenesis of Type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic α-cells occurs prior to impaired glucose stimulated insulin secretion (GSIS) from β-cells. However, whether hyperglucagonemia is causally linked to β-cell dysfunction remains unclear. Here w...

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Detalhes bibliográficos
Main Authors: Song, Woo-Jin, Mondal, Prosenjit, Wolfe, Andrew, Alonso, Laura C., Stamateris, Rachel, Ong, Benny W. T., Lim, Owen C., Yang, Kil S., Radovick, Sally, Novaira, Horacio F., Farber, Emily A., Farber, Charles R., Turner, Stephen D., Hussain, Mehboob A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058888/
https://ncbi.nlm.nih.gov/pubmed/24703698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.005
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