Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G(2) arrest

BACKGROUND: HIV-1 Vpr-mediated G(2) cell cycle arrest is dependent on the interaction of Vpr with an E3 ubiquitin ligase that contains damage-specific DNA binding protein 1 (DDB1), Cullin 4A (Cul4A), DDB1 and Cul4-associated factor 1 (DCAF1), and Rbx1. Vpr is thought to associate directly with DCAF1...

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Hlavní autoři: Hakata, Yoshiyuki, Miyazawa, Masaaki, Landau, Nathaniel R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058697/
https://ncbi.nlm.nih.gov/pubmed/24912982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-11-108
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