HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4A(VPRBP) E3 Ubiquitin Ligase

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but factors directly engaged in this process remain unknown. We used tandem affinity purification to isolate native Vpr comp...

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Bibliographic Details
Main Authors: Belzile, Jean-Philippe, Duisit, Ghislaine, Rougeau, Nicole, Mercier, Johanne, Finzi, Andrés, Cohen, Éric A
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914068/
https://ncbi.nlm.nih.gov/pubmed/17630831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030085
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