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Defining the Interactions and Role of DCAF1/VPRBP in the DDB1-Cullin4A E3 Ubiquitin Ligase Complex Engaged by HIV-1 Vpr to Induce a G(2) Cell Cycle Arrest
HIV viral protein R (Vpr) induces a cell cycle arrest at the G(2)/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate specificity receptor DCAF1. Since no high resolution s...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928422/ https://ncbi.nlm.nih.gov/pubmed/24558487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089195 |
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