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Regio- and Stereoselective 1,2-Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers

The first example of C-alkylation of 1,2-dihydropyridines with alkyl triflates and Michael acceptors was developed to introduce quaternary carbon centers with high regio- and diastereoselectivity. Hydride or carbon nucleophile addition to the resultant iminium ion also proceeded with high diastereos...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Duttwyler, Simon, Chen, Shuming, Lu, Colin, Mercado, Brandon Q., Bergman, Robert G., Ellman, Jonathan A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058641/
https://ncbi.nlm.nih.gov/pubmed/24604837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201310517
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