Probing Binding and Cellular Activity of Pyrrolidinone and Piperidinone Small Molecules Targeting the Urokinase Receptor

The urokinase receptor (uPAR) is a cell-surface protein that is part of an intricate web of transient and tight protein interactions that promote cancer cell invasion and metastasis. Here we evaluate the binding and biological activity of a new class of pyrrolidinone (3) and piperidinone (4) compoun...

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Hauptverfasser: Mani, Timmy, Liu, Degang, Zhou, Donghui, Li, Liwei, Knabe, William Eric, Wang, Fang, Oh, Kyungsoo, Meroueh, Samy O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058332/
https://ncbi.nlm.nih.gov/pubmed/24115356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300340
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