Small-Molecule Inhibition of the uPAR·uPA Interaction: Synthesis, Biochemical, Cellular, in vivo Pharmacokinetics and Efficacy Studies in Breast Cancer Metastasis

The uPAR·uPA protein-protein interaction (PPI) is involved in signaling and proteolytic events that promote tumor invasion and metastasis. A previous study had identified 4 (IPR-803) from computational screening of a commercial chemical library and shown that the compound inhibited uPAR·uPA PPI in c...

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Detalhes bibliográficos
Main Authors: Mani, Timmy, Wang, Fang, Knabe, William Eric, Sinn, Anthony L., Khanna, May, Jo, Inha, Sandusky, George E., Sledge, George W., Jones, David R., Khanna, Rajesh, Pollok, Karen E., Meroueh, Samy O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625246/
https://ncbi.nlm.nih.gov/pubmed/23411397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.047
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