Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

The PI3K/Akt/mTOR pathway is overactivated and heat shock protein (HSP) 90 is overexpressed in common cancers. We hypothesized that targeting both pathways can kill intrahepatic cholangiocarcinoma (CCA) cells. HSP90 and PTEN protein expression was evaluated by immunohistochemical staining of samples...

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Hoofdauteurs: Chen, Ming-Huang, Chiang, Kun-Chun, Cheng, Chi-Tung, Huang, Shih-Chiang, Chen, Yeng-Yang, Chen, Tsung-Wen, Yeh, Ta-Sen, Jan, Yi-Yin, Wang, Hsi-Ming, Weng, Jiang-Jie, Chang, Peter Mu-Hsin, Liu, Chun-Yu, Li, Chung-Pin, Chao, Yee, Chen, Ming-Han, Huang, Chi-Ying F., Yeh, Chun-Nan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058012/
https://ncbi.nlm.nih.gov/pubmed/24796583
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