Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

The PI3K/Akt/mTOR pathway is overactivated and heat shock protein (HSP) 90 is overexpressed in common cancers. We hypothesized that targeting both pathways can kill intrahepatic cholangiocarcinoma (CCA) cells. HSP90 and PTEN protein expression was evaluated by immunohistochemical staining of samples...

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Dades bibliogràfiques
Autors principals: Chen, Ming-Huang, Chiang, Kun-Chun, Cheng, Chi-Tung, Huang, Shih-Chiang, Chen, Yeng-Yang, Chen, Tsung-Wen, Yeh, Ta-Sen, Jan, Yi-Yin, Wang, Hsi-Ming, Weng, Jiang-Jie, Chang, Peter Mu-Hsin, Liu, Chun-Yu, Li, Chung-Pin, Chao, Yee, Chen, Ming-Han, Huang, Chi-Ying F., Yeh, Chun-Nan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058012/
https://ncbi.nlm.nih.gov/pubmed/24796583
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