Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models

Heat shock protein 90 is a molecular chaperon that maintains the correct folding and function of multiple client proteins. The inhibition of heat shock protein 90, which leads to the simultaneous degradation of multiple proteins involved in oncogenic signaling pathways, has revealed an innovative st...

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Udgivet i:Oncotarget
Main Authors: Lin, Shu-Fu, Lin, Jen-Der, Hsueh, Chuen, Chou, Ting-Chao, Yeh, Chun-Nan, Chen, Ming-Huang, Wong, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522292/
https://ncbi.nlm.nih.gov/pubmed/28476040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17180
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