Impact of regulated secretion on anti-parasitic CD8 T cell responses

CD8 T cells play a key role in defense against the intracellular parasite Toxoplasma but why certain CD8 responses are more potent than others is not well understood. Here, we describe a parasite antigen ROP5 that elicits a modest CD8 T cell response in genetically susceptible mice. ROP5 is secreted...

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Bibliografiske detaljer
Main Authors: Grover, Harshita Satija, Chu, H. Hamlet, Kelly, Felice D., Yang, Soo Jung, Reese, Michael L., Blanchard, Nicolas, Gonzalez, Federico, Chan, Shiao Wei, Boothroyd, John C., Shastri, Nilabh, Robey, Ellen A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057976/
https://ncbi.nlm.nih.gov/pubmed/24857659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.031
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