Continuous effector T cell production in a controlled persistent infection is sustained by a proliferative subset of memory-effector hybrid phenotype

Highly functional CD8(+) effector T (Teff) cells can persist in large numbers during controlled persistent infections, as exemplified by rare HIV-infected individuals who control the virus. Here we examined the cellular mechanisms that maintain ongoing T effector responses using a mouse model for pe...

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Publicado no:Immunity
Main Authors: Chu, H. Hamlet, Chan, Shiao-Wei, Gosling, John Paul, Blanchard, Nicolas, Tsitsiklis, Alexandra, Lythe, Grant, Shastri, Nilabh, Molina-París, Carmen, Robey, Ellen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956557/
https://ncbi.nlm.nih.gov/pubmed/27421704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.013
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