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Coping with loss of perfection in the MHC class I peptide repertoire

The MHC class I molecules present thousands of peptides (pMHC I) on the cell surface for immune surveillance by CD8 T cells. The pMHC I repertoire normally contains peptides of perfect length and sequences suitable for binding each MHC I. The peptides are made by first fragmenting cytoplasmic protei...

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Bibliografiske detaljer
Main Authors: Blanchard, Nicolas, Shastri, Nilabh
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705891/
https://ncbi.nlm.nih.gov/pubmed/18243675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2007.12.004
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