The Synthesis, Characterization, and Application of (13)C-Methyl Isocyanide as an NMR Probe of Heme Protein Active Sites

The cytochromes P450 (CYPs) play a central role in a variety of important biological oxidations, such as steroid synthesis and the metabolism of xenobiotic compounds, including most drugs. Because CYPs are frequently assayed as drug targets or as anti-targets, tools that provide confirmation of acti...

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Bibliographic Details
Main Authors: McCullough, Christopher, Pullela, Phani Kumar, Im, Sang-Choul, Waskell, Lucy, Sem, Daniel
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057429/
https://ncbi.nlm.nih.gov/pubmed/23475666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-321-3_4
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