Genome-Wide Binding of MBD2 Reveals Strong Preference for Highly Methylated Loci

MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. In this study we adopted an MBD2 tagging-approach to study its genome wide binding characteristics. We show that in vivo MBD2 is mainly recruited to CpG island promot...

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Detalhes bibliográficos
Main Authors: Menafra, Roberta, Brinkman, Arie B., Matarese, Filomena, Franci, Gianluigi, Bartels, Stefanie J. J., Nguyen, Luan, Shimbo, Takashi, Wade, Paul A., Hubner, Nina C., Stunnenberg, Hendrik G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057170/
https://ncbi.nlm.nih.gov/pubmed/24927503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099603
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