Anti-nonGal specific combination treatment with an anti-idiotypic Ab and an inhibitory small molecule mitigates the xenoantibody response

BACKGROUND: B cell depletion significantly extends survival of α-1,3-galactosyltranferase knockout (GTKO) porcine organs in pig-to-primate models. Our previous work demonstrated that the anti-nonGal xenoantibody response is structurally restricted. Selective inhibition of xenoantigen-xenoantibody in...

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Bibliografiset tiedot
Päätekijät: Stewart, John M., Tarantal, Alice F., Chen, Yan, Appleby, Nancy, Fuentes, Tania, Lee, C. Chang I., Salvaris, Evelyn J., d'Apice, Anthony J.F., Cowan, Peter J., Kearns-Jonker, Mary
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056685/
https://ncbi.nlm.nih.gov/pubmed/24635144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12096
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