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Anti-nonGal specific combination treatment with an anti-idiotypic Ab and an inhibitory small molecule mitigates the xenoantibody response
BACKGROUND: B cell depletion significantly extends survival of α-1,3-galactosyltranferase knockout (GTKO) porcine organs in pig-to-primate models. Our previous work demonstrated that the anti-nonGal xenoantibody response is structurally restricted. Selective inhibition of xenoantigen-xenoantibody in...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4056685/ https://ncbi.nlm.nih.gov/pubmed/24635144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12096 |
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