Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction

INTRODUCTION: Diaphragm weakness induced by prolonged mechanical ventilation may contribute to difficult weaning from the ventilator. Hypercapnia is an accepted side effect of low tidal volume mechanical ventilation, but the effects of hypercapnia on respiratory muscle function are largely unknown....

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Main Authors: Schellekens, Willem-Jan M, van Hees, Hieronymus WH, Kox, Matthijs, Linkels, Marianne, Acuña, Gilberto L Andrade, Dekhuijzen, PN Richard, Scheffer, Gert Jan, van der Hoeven, Johannes G, Heunks, Leo MA
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056638/
https://ncbi.nlm.nih.gov/pubmed/24506836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13719
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