A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

Many cancers overexpress a member of the bcl-2 family of inhibitors of apoptosis. To determine the role of these proteins in maintaining cancer cell viability, an adenovirus vector that expresses bcl-xs, a functional inhibitor of these proteins, was constructed. Even in the absence of an exogenous a...

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Bibliografiske detaljer
Main Authors: Clarke, M F, Apel, I J, Benedict, M A, Eipers, P G, Sumantran, V, González-García, M, Doedens, M, Fukunaga, N, Davidson, B, Dick, J E
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40563/
https://ncbi.nlm.nih.gov/pubmed/7479929
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