A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

Many cancers overexpress a member of the bcl-2 family of inhibitors of apoptosis. To determine the role of these proteins in maintaining cancer cell viability, an adenovirus vector that expresses bcl-xs, a functional inhibitor of these proteins, was constructed. Even in the absence of an exogenous a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Clarke, M F, Apel, I J, Benedict, M A, Eipers, P G, Sumantran, V, González-García, M, Doedens, M, Fukunaga, N, Davidson, B, Dick, J E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40563/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11024
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