Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin

INTRODUCTION: Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected m...

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Main Authors: Müller-Redetzky, Holger C, Will, Daniel, Hellwig, Katharina, Kummer, Wolfgang, Tschernig, Thomas, Pfeil, Uwe, Paddenberg, Renate, Menger, Michael D, Kershaw, Olivia, Gruber, Achim D, Weissmann, Norbert, Hippenstiel, Stefan, Suttorp, Norbert, Witzenrath, Martin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056010/
https://ncbi.nlm.nih.gov/pubmed/24731244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13830
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