Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin

INTRODUCTION: Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected m...

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Detalhes bibliográficos
Main Authors: Müller-Redetzky, Holger C, Will, Daniel, Hellwig, Katharina, Kummer, Wolfgang, Tschernig, Thomas, Pfeil, Uwe, Paddenberg, Renate, Menger, Michael D, Kershaw, Olivia, Gruber, Achim D, Weissmann, Norbert, Hippenstiel, Stefan, Suttorp, Norbert, Witzenrath, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056010/
https://ncbi.nlm.nih.gov/pubmed/24731244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13830
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