Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication

BACKGROUND: Osteopontin (OPN) is a Hedgehog (Hh)-regulated cytokine that is up-regulated during chronic liver injury, and directly promotes fibrosis. We reported that Hh-signaling enhances viral permissiveness and replication in HCV-infected cells. Hence, we hypothesized that OPN directly promotes H...

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Main Authors: Choi, Steve S, Claridge, Lee C, Jhaveri, Ravi, Swiderska-Syn, Marzena, Clark, Paul, Suzuki, Ayako, Pereira, Thiago A, Mi, Zhiyong, Kuo, Paul C, Guy, Cynthia D, Pereira, Fausto EL, Diehl, Anna Mae, Patel, Keyur, Syn, Wing-Kin
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055032/
https://ncbi.nlm.nih.gov/pubmed/24438228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20130473
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