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Time-resolved FRET Reveals the Structural Mechanism of SERCA-PLB Regulation
We have used time-resolved fluorescence resonance energy transfer (TR-FRET) to characterize the interaction between phospholamban (PLB) and the sarcoplasmic reticulum (SR) Ca-ATPase (SERCA) under conditions that relieve SERCA inhibition. Unphosphorylated PLB inhibits SERCA in cardiac SR, but inhibit...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054823/ https://ncbi.nlm.nih.gov/pubmed/24813991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.04.166 |
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