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Time-resolved FRET Reveals the Structural Mechanism of SERCA-PLB Regulation

We have used time-resolved fluorescence resonance energy transfer (TR-FRET) to characterize the interaction between phospholamban (PLB) and the sarcoplasmic reticulum (SR) Ca-ATPase (SERCA) under conditions that relieve SERCA inhibition. Unphosphorylated PLB inhibits SERCA in cardiac SR, but inhibit...

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Detalhes bibliográficos
Main Authors: Dong, Xiaoqiong, Thomas, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054823/
https://ncbi.nlm.nih.gov/pubmed/24813991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.04.166
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