PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

BACKGROUND: DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the relationship varies with the specific differentiation process. Conversion of...

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Autors principals: de la Rica, Lorenzo, Rodríguez-Ubreva, Javier, García, Mireia, Islam, Abul BMMK, Urquiza, José M, Hernando, Henar, Christensen, Jesper, Helin, Kristian, Gómez-Vaquero, Carmen, Ballestar, Esteban
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054781/
https://ncbi.nlm.nih.gov/pubmed/24028770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-9-r99
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