Tet2 facilitates the de-repression of myeloid target genes during C/EBPa induced transdifferentiation of pre-B cells

The methylcytosine hydroxylase Tet2 has been implicated in hematopoietic differentiation and the formation of myeloid malignancies when mutated. An ideal system to study the role of Tet2 in myelopoeisis is C/EBPa induced transdifferentiation of pre-B cells into macrophages. Here we found that C/EBPa...

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Bibliographic Details
Main Authors: Kallin, Eric M., Rodríguez-Ubreva, Javier, Christensen, J esper, Cimmino, Luisa, Aifantis, Iannis, Helin, Kristian, Ballestar, Esteban, Graf, Thomas
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667550/
https://ncbi.nlm.nih.gov/pubmed/22981865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.007
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