Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1

We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shen, Ruizhong, Kappes, John C., Smythies, Lesley E., Richter, Holly E., Novak, Lea, Smith, Phillip D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Virus-Cell Interactions
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054437/
https://ncbi.nlm.nih.gov/pubmed/24741097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00766-14
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