The Impact of the Hepatitis B Virus Polymerase rtA181T Mutation on Replication and Drug Resistance Is Potentially Affected by Overlapping Changes in Surface Gene

The emergence of drug-resistant hepatitis B virus (HBV) is a major problem for antiviral treatment in chronic hepatitis B infection. In this study, we analyzed the evolution of drug-resistant mutations and characterized the effects of the rtA181T and rtI233V mutations on viral replication and drug r...

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Detalhes bibliográficos
Main Authors: Ahn, Sung Hyun, Park, Yong Kwang, Park, Eun-Sook, Kim, Jeong Han, Kim, Doo Hyun, Lim, Keo-Heun, Jang, Moon Sun, Choe, Won Hyeok, Ko, Soon Young, Sung, In-Kyung, Kwon, So Young, Kim, Kyun-Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054353/
https://ncbi.nlm.nih.gov/pubmed/24696492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00635-14
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