Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance

The emergence of compensatory mutations in the polymerase gene of drug resistant hepatitis B virus (HBV) is associated with treatment failure. We previously identified a multi-drug resistant HBV mutant, which displayed resistance towards lamivudine (LMV), clevudine (CLV), and entecavir (ETV), along...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Ahn, Sung Hyun, Kim, Doo Hyun, Lee, Ah Ram, Kim, Beom Kyung, Park, Yong Kwang, Park, Eun-Sook, Ahn, Sang Hoon, Shin, Gu-Choul, Park, Soree, Kang, Hong Seok, Rhee, Jin-Kyu, Yang, Sung-Il, Chong, Youhoon, Kim, Kyun-Hwan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556173/
https://ncbi.nlm.nih.gov/pubmed/26322642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136728
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