Mutations in the Main Cytoplasmic Loop of the GABA(A) Receptor α(4) and δ Subunits Have Opposite Effects on Surface Expression

We examined the role of putative trafficking sequences in two GABA(A) receptor subunits: α(4) and δ. These subunits assemble with a β subunit to form a subtype of GABA(A) receptor involved in generating the “tonic” outward current. Both α(4) and δ subunits contain dibasic retention motifs in homolog...

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Hlavní autoři: Bracamontes, John R., Li, Ping, Akk, Gustav, Steinbach, Joe Henry
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054001/
https://ncbi.nlm.nih.gov/pubmed/24723490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092791
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