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To be or not to be a piRNA: genomic origin and processing of piRNAs

Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.

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Bibliografiska uppgifter
Huvudupphovsmän: Le Thomas, Adrien, Tóth, Katalin Fejes, Aravin, Alexei A
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053809/
https://ncbi.nlm.nih.gov/pubmed/24467990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb4154
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