Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

BACKGROUND: The global effect of copy number and epigenetic alterations on miRNA expression in cancer is poorly understood. In the present study, we integrate genome-wide DNA methylation, copy number and miRNA expression and identify genetic mechanisms underlying miRNA dysregulation in breast cancer...

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Autori principali: Aure, Miriam Ragle, Leivonen, Suvi-Katri, Fleischer, Thomas, Zhu, Qian, Overgaard, Jens, Alsner, Jan, Tramm, Trine, Louhimo, Riku, Alnæs, Grethe I Grenaker, Perälä, Merja, Busato, Florence, Touleimat, Nizar, Tost, Jörg, Børresen-Dale, Anne-Lise, Hautaniemi, Sampsa, Troyanskaya, Olga G, Lingjærde, Ole Christian, Sahlberg, Kristine Kleivi, Kristensen, Vessela N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053776/
https://ncbi.nlm.nih.gov/pubmed/24257477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-11-r126
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